Pregnancy-associated breast cancer (PABC) is relatively rare. PABC is defined as breast cancer occurring during pregnancy, first postpartum year, or anytime during lactation. It is estimated to occur in 1 every 3000 pregnancies. On the other hand, it is the most common cancer during pregnancy, the incidence of PABC is expected to rise in developed countries, while historically PABC was always thought to have poor prognosis this is not universally true, it continues to represent a special challenge for early diagnosis and treatment options.
Neoadjuvant therapy refers to the systemic treatment of breast cancer before definitive surgery, it is also called preoperative therapy. Neoadjuvant therapy was initially used for patients with the advanced inoperable disease, however, it is now proved to be beneficial in different subsets of patients including those with early-stage operable breast cancer.